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Some patients taking Wegovy (semaglutide 2.4 mg) report feeling colder than usual, particularly during initial treatment months

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Specifically, patients with T2DM tend to achieve less weight loss (17, 23)

Beyond their established role in diabetes management, GLP-1 RAs have demonstrated cardiovascular protection, potential neuroprotective effects, and improvement in inflammation and endothelial function, positioning them as promising therapeutic agents for the geroscience field 1,2,3,5,6,7

This means that new or worsening constipation isnt unusual